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Summary Keywords hepatocytes, hepatotoxicity, glutathione, itraconazole, canine Citation Kirk NM, Vieson MD, Selting KA and Reinhart JM (2021) Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione

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In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress

In addition, some proteins can stimulate tumor cells to switch from oxidative phosphorylation (OXPHOS) to glycolysis, in turn leading to lower levels of GSH, which suppress the activity of GPX4 and boost the accumulation of lipids, thus resulting in ferroptosis [21,22,23,24]