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(87) reported that prolong (16 wks) treatment of Hp-infected mice with specific COX-2 blocker (NS-398) reduced mucosal inflammation provoked by Hp infection and reduce the activity of COX-2, but failed to effect the COX-2 expression and bacterial colonization in the stomach

The FDAs own scientists recommended against it

[0275] The nucleic acid compositions described herein {e.g., nucleic acids encoding all or a portion of an anti-ALPP/ALPPL2 antibody or immunoconjugate) while often in a native sequence (except for modified restriction sites and the like), from either cDNA, genomic or mixtures thereof may be mutated, in accordance with standard techniques to provide variant sequences