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46 In the rare instances that medication cessation does not lead to cholestasis resolution, cholestyramine or ursodeoxycholic acid has been used, followed by rifampicin and opioid antagonists if the first-line agents fail

Its distinctive inactive-to-active conversion within the tumor microenvironment augments metabolic targeting and selectivity, which underscores its potential as a groundbreaking therapeutic strategy [186, 187]