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10.1038/s41419-021-04478-x 146 WangJ

Glutathione synthesis is controlled by the first enzyme in the synthetic pathway, glutamate-cysteine ligase (GCL), otherwise known as -glutamylcysteine synthetase, which creates -L-glutamyl-L-cysteine (GC)

DNMT inhibitors offer a promising approach to reverse these epigenetic alterations and restore the expression of silenced genes, ultimately inhibiting tumor growth and sensitizing TNBC cells to conventional chemotherapeutic agents and targeted therapies