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Investigators across the field of IVD research have been working to elucidate the mechanisms behind the formation of this multifaceted structure, which may identify new therapeutic targets and inform development of novel regenerative strategies

Stimulates new blood vessel growth to improve nutrient delivery to injured tissues through VEGFR2 pathway activation Enhances fibroblast activity and collagen synthesis for stronger tissue repair and improved structural integrity Increases GH receptor expression making tissues more responsive to natural repair signals Modulates inflammatory response to reduce pain and prevent excessive tissue damage from prolonged inflammation Cell migration represents another critical mechanism