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As one of the first cytokines to be discovered over half a century ago, it was initially described as a lymphocyte-derived soluble immune factor that inhibited the random migration of macrophages out of capillary tubes (David, 1966)

To examine whether retroductal injection of these hits preserves functional secretion, stimulated saliva secretion was evaluated 12 wks post-irradiation

doi: 10.1016/j.fct.2017.07.050, Summary Keywords gut microbiota, polyphenol-derived microbial metabolites, polyphenols, sleep, urolithin A Citation Pinaffi-Langley ACC, Zuraikat FM, St-Onge M-P and Yabluchanskiy A (2026) Potential impact of urolithin A on pathways relevant to sleep health: a mini review

Both approaches reflect a tiered model of research depth starting simple and building toward more comprehensive compound profiles as the research base expands