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Treatment guidelines typically suggest adding a new agent instead of switching, particularly if the initial medication provided some benefit [87,188,189,190]

In PD animal models, Bcl-2 family proteins exhibit abnormal expression following neuronal lesions, which triggers apoptotic cascades and contributes to further degeneration of brain regions (Table 1)

Interestingly, the vast majority of these compounds can alleviate UC by Mechanism , , and

Interestingly, BCL6 overexpression extends beyond lymphomas, being implicated in breast cancer [34], ovarian cancer [[35], glioma [36], chronic myeloid leukemia [52], non-small cell lung cancer [53] and so on