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Regarding avian/fish model limitations, we incorporated human clinical data on biomarkers, microbiome profiling, and liver disease outcomes to enhance translational relevance

Then, through an extensive analysis of in vitro and in vivo studies, we highlight the adverse effects of NBNs exposure, including the generation of reactive oxygen species (ROS), oxidative stress, inflammation, cytotoxicity, genotoxicity, and immunotoxicity

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The FDAs accelerated approval was based on a study in 124 patients with locally advanced or metastatic NSCLC with the KRASG12C mutation who had previously been treated with an immune checkpoint inhibitor or a platinum-based chemotherapy