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In fact, in vivo studies have shown that Nrf2 signaling has an essential role in limiting neuropathies (Arruri et al., 2017), arthritis (Ferrandiz et al., 2018), colitis (Xu et al., 2018), pneumonia (Athale et al., 2012), pulmonary fibrosis (Yan et al., 2017), skin diseases (Schafer and Werner, 2015), liver (Bae et al., 2013), and kidney damage (Shen et al., 2017), as well as affecting tumor development (Sporn and Liby, 2012)