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Notably, both quercetin and resveratrol prevent iron-catalyzed hydroxyl radical formation, providing ferroptosis inhibition independent of Nrf2/ARE pathway

Further supporting these findings, a 2024 study by Kuryata and Frolova investigated the efficacy of 2 grams per day of L-carnitine in post-COVID patients dealing with long-term systemic complications

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Another area of increasing interest is the signaling role of astrocytic lactate beyond its role as an energy substrate: emerging evidence demonstrates that lactate induces histone lysine lactylation (e.g., H3K18la), activating transcription factors like Klf4 to regulate genes associated with synaptic plasticity (e.g., Arc, CREB), thereby contributing to epigenetic remodeling during long-term memory formationa mechanism that underscores metabolic signaling as a target for cognitive enhancement (Yao et al., 2023)