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In one study, H9c2 cells exposed to 35 mM glucose for 24 h exhibited significantly increased intracellular 4-HNE and MDA levels compared to normoglycemic controls, accompanied by oxidative stress

[32] found that ethanol-induced fatty liver and cirrhosis in wild-type and humanized CYP2E1 knock-in mice but attenuated ethanol-induced fatty liver in CYP2E1 knockout mice

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In this context, oxidative stress can also induce biological reactions in the cytoskeletal structure of TM cells [88,89]