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Besides altering the acidbase balance, HS also alters electrolyte concentrations, particularly Na + , K + , and Cl , which are crucial for intracellular and extracellular fluid homeostasis (138)

Future research is also needed to explore the antidepressant effects of LAC acting as part of a system network with other important mediators of brain plasticity in comparison with classical antidepressant drugs with particular focus on the effects in specific phenotypes of depression well-characterized not only for the individual endogenous levels of LAC but also for the corresponding changes in metabolic and inflammatory pathways as well as for history of adverse childhood experiences

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