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doi: 10.1016/j.neurol.2017.08.005 5 HoehnMMYahrMD

Protons play a crucial role in biochemical networks because changes in intracellular pH affect cell functioning at different levels as it impacts protein folding, enzyme activities, and the protonation of biological macromolecules, lipids, and other metabolites

Similar findings of lacking a control mechanism used by HC subjects were also demonstrated in the TRP pathway from these same FENNS patients (Yao et al., 2010a)