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Data availability All external transcriptomic reference cohorts employed in this work are publicly available from the NCBI Gene Expression Omnibus (GEO) and can be downloaded without restriction from the GEO website ( under accession numbers GSE29265, GSE33630, GSE53157, GSE65144, and GSE76039

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An imbalance between antioxidants and oxidants directs to the state of oxidative stress, which has the potential to cause damage to biological molecules, including proteins, carbohydrates, lipids, and DNA ( Antioxidants are crucial in fighting oxidative stress as they neutralize or remove free radicals through electron donation ( 4.3 Inflammation Regarding the inflammatory effect of LZD, the present study found that serum IL1- as well as TNF- in LZD-treated rats were significantly elevated compared to non-treated control rats