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Immune-related toxicities such as dermatitis, colitis, or endocrinopathies likely reflect enhanced T-cell activation and systemic immune engagement ( Furthermore, lymphocyte-based markers, such as LMR and absolute lymphocyte count, may serve as surrogate indicators of preserved immune competence, a prerequisite for effective tumor-specific responses

349 Targeting allele-specific compounds Allele-specific compounds that target a single mutant or a group of similar mutants were proposed several decades ago

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