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This reveals protein-glutathionylation to be amongst the most common forms of cysteine-PTM found within cells (Figure S1A and B)

In untargeted metabolomics of T1DM patients, 3,4-DHBA was established as an independent risk marker for DR stage progression ( Vitreous-based studies revealed a broad spectrum of upregulated metabolites including allantoin, lactate, proline, dimethylglycine, -ketoglutarate and pyruvate (Tomita et al., 2021), while ascorbate, 5-oxoproline, and fumarate exhibited decreased levels alongside a downregulation of glycolysis and activation of the pentose phosphate pathway ( Metabolic pathways involving carnitine, tryptophan, primary bile acid biosynthesis, pantothenate and CoA biosynthesis, glutathione, glycine, serine, threonine, cysteine, pentose phosphate, methionine, and aminoacyl-tRNA biosynthesis were significantly linked with DR (Sumarriva et al., 2019

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[DOI] [PMC free article] [PubMed] [Google Scholar] 292.Young SZ, Bordey A