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Importantly, several additional regulatory components such as Munc13-1, complexins, Syt1, -SNAP and NSF likely orchestrate SNARE complex assembly preventing the formation of unproductive intermediates and promoting forward directionality (He et al., 2017

In addition, two open-label, phase 2 clinical trials have been fulfilled, where the BAFF/BLyS targeting belimumab as monotherapy seemed to be efficient for pSS patients ( In a further study, the combination of belimumab and rituximab was tested in a phase 2 clinical trial in pSS patients (104)

Attenuating ER stress with exogenous H 2 S represents a promising therapeutic strategy for PH with high translational potential (Wu et al., 2019)

To avoid the adventitious reduction of SmTrx by NADPH, the stopped-flow instrument was used in double mixing mode and the SmTrx, NADPH, and SmTGR solutions were loaded into individual drive syringes