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17 To our knowledge, there are no studies that assess the direct effect of caffeine absorption through colonic mucosa

However, a method of increasing GSH concentrations in this population was not discussed

Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people

through biochemical purification, and it is the main enzyme in mammalian cells that catalyzes the reduction of PLOOHs, while reduction of GPX4 leads to the accumulation of PLOOHs, which causes rapid and irreversible damage to the plasma membrane, triggering lipid peroxidation and resulting in ferroptosis in cells [5, 46, 47]