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STW3-VI pre-treatment lead to a concentration-dependent abolishment (of glutamate/NMDA-induced decrease of viability) by 25% ( p 0.01) and 50% ( p 0.01) at 10 g/ml STW3-VI in comparison to 0.1 mM glutamate (Figure 3A) or 0.1 mM NMDA (Figure 3B) treatment, indicating a cytoprotective effect of STW3-VI against glutamate- or NMDA-induced neurotoxicity

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Intervening and treating oxidative stress is one of the most effective techniques for improving the pathogenetic status of ASD patients

Finally, we explored the possible signaling pathways by which GPX1 was involved in protecting SGNs against peroxynitrite-induced injury