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High LPCAT3 expression upregulates the level of unsaturated fatty acids in biofilms and increases the sensitivity of cells toward ferroptosis

Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through yap/tead4/acadl axis in hepatocellular carcinoma

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For example, we and others have found that renal cancer cells (RCC) with loss of VHL (Von Hippel-Lindau), a tumor suppressor that destabilizes HIF1A via ubiquination, are significantly sensitive to ascorbate treatment compared to VHL-proficient cells