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3.2 Brown AT: thermogenic organ for heat production and energy expenditure Brown AT (BAT) is characterized by the presence of UCP1 (thermogenin), a specialized mitochondrial protein that uncouples the electron transport chain from ATP synthesis by allowing protons to leak across the inner mitochondrial membrane, thereby dissipating the proton gradient as heat rather than using it for ATP production ( The discovery of active BAT in adult humans in 2009 fundamentally changed understanding of metabolic regulation ( Batokines regulate whole-body metabolism by modifying glucose handling, insulin responses, and inflammatory signals ( 3.3 Beige adipocytes: inducible thermogenic cells for metabolic flexibility Beige adipocytes are a unique thermogenic cell population that emerge within WAT through a process called browning or beiging, triggered by various environmental stimuli such as cold exposure, -adrenergic activation, and certain hormonal signals ( The molecular pathways governing beige adipose cells utilize specific transcriptional controllers for development and function

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SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

Shang F, Lu M, Dudek E, Reddan J, Taylor A