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Figure 2C highlights the immunological arm of this axis, showing how SCFAs and related metabolites polarize macrophages toward an M2-like phenotype, promote Treg differentiation and increase IL-10/TGF- production, thereby dampening systemic and islet inflammation and indirectly preserving -cell function

As with any nutritional supplement, results can vary based on your nutrition, training, other lifestyle factors, and more

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One can assume that eating a KD high in indigestible carbohydrates has a more beneficial effect on the microbiome, and that the amount of indigestible carbohydrate is more important for the microbiota than the state of ketosis by itself