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This aligns with AMPK's role as an energy sensor: when cellular ATP is low (fasted state), AMPK activation triggers a stronger metabolic response

Cortisone injections may be appropriate for individuals who: Have not responded well to other treatments due to pain

For example, the four-hour threshold for numerator component (3), transfer boarding time, was developed per recommendations from The Joint Commission (TJC) and the American College of Emergency Physicians (ACEP)