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Figure 6 Discussion Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure, whereby some cancer cells enter a reversible drug-tolerant persister state in response to treatment (27)

Western blot assay Cells (1 10 6 ) were grown to 7080% confluency and treated with DMSO control, (1S,3R)-RSL3 (RSL3, Catalog # 19,288, Cayman Chemical, MI) or Fer1 (Medchemexpress, NJ) as per the experiments