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Pro dehydrogenase metabolism maintains mtROS homeostasis via sirtuin 1/superoxide dismutase 2 pathways

Intestinal permeability, or leaky gut, is a common trigger in autoimmunity, allowing undigested food particles and toxins to enter the bloodstream, which provokes an immune response and fuels inflammation

Curcumin exerts its antioxidant activities directly, by scavenging superoxide anion and hydroxyl radicals, and indirectly by, among others, activating the Nrf2 pathway and inducing the expression of different antioxidant enzymes such as HO-1 (Lee et al., 2010b

These results are consistent with the observations suggesting that the statement that NAC is solely an anti-apoptotic agent is probably an over-generalization [49]