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Neurofibromin (Nf1) is required for skeletal muscle development

5 Prostaglandins : PGI 2 , which is another endothelium-dependent vasodilator, relaxes the VSMC

doi: 10.1016/j.eururo.2018.09.030 53 BlairMCNeinastMDAranyZ

Cancer cells can be functionally shaped to fit the TME for tumor cell growth and development by secreting various cytokines, chemokines, and other factors that lead to reprogramming of the surrounding cells (139)