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We further speculated that loss of the extracellular GSH pool in gsh2 mutants could change the external environment and consequently affect extracellular redox homeostasis

The plasma concentrationtime profiles showed a rapid one-peak course until T max , followed by a multiphasic decrease, which probably reflected a distribution and elimination phase

Jafari, N., Broer, L., van Duijn, C

This conversion can be inhibited by targeting mitochondrial ROS with antioxidants or selenium, further highlighting the importance of ROS in fibroblast-to-myofibroblast conversion [81, 82]