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Careful consideration must be given to the individual responses and the existing discrepancies among the microbiomes of ME/CFS patients compared to healthy individuals, emphasizing the delicate interplay between pharmacological treatments and gut health [181,182,183,184]

(110) showed that endogenously generated NO and ROS contribute to HIF-1 accumulation by inhibiting prolyl hydroxylase domain proteins (PHDs) via S-nitrosation of PHD2, thus preventing HIF-1 degradation during hypoxia (110)