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*Correspondence: Michela Rubin, [email protected]

The three formulas the calculator uses: Concentration (mg/mL) = vial mg bacteriostatic water mL Units to draw = (target mcg (vial mg 1000)) water mL 100 Doses per vial = (vial mg 1000) target mcg, rounded down A 5 mg vial reconstituted with 2 mL of bacteriostatic water is 2.5 mg/mL, or 25 mcg per unit

The consequence is easy to understate: a substantial fraction of the evidence that DSIP exists endogenously and varies with sleep rests on assays that cannot fully distinguish DSIP from related material

identified that, uniquely among dopamine precursors or metabolic components, dopamine itself induces cellular iron accumulation during its metabolism (127)