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Other studies have shown that the coordinated modulation of STAT6 and p38 MAPK exhibited potential effects on the induction of IL4 and IL13 and that p38 MAPK could directly regulate the activity of the transactivation domain of STAT6 [47,48,49]

58 In the 3-month study with 20 women mentioned earlier, a significant skin-hydration increase (21%) was noted in the Pycnogenol group, particularly in women presenting with dry skin before Pycnogenol intake

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Stabilization of NIK results in the stimulation of downstream noncanonical signaling events