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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

doi: 10.1111/odi.13265 149 NajiAEitokuMFavierBDeschaseauxFRouas-FreissNSuganumaN

This method is considered particularly effective for conditions like non-alcoholic fatty liver disease, where intravenous glutathione has been used to support detoxification systems and combat oxidative stress

Jarskog LF, Dong Z, Kangarlu A, Colibazzi T, Girgis RR, Kegeles LS, et al