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ETT has been evolutionarily conserved through time leading to much speculation and interest about ERGO's importance to human health (Reference Oumari, Goldfuss and Stoffels10)

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Katsuta O, Hiratsuka H, Matsumoto J et al (1994) Cadmium-induced osteomalacic and osteopetrotic lesions in ovariectomized rats

The mitochondrial electron transport chain (ETC) and NADPH oxidase (NOX) are key sources of ROS in -cells, and their dysfunction further promotes oxidative stress