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Together, our study uncovers a regulatory layer of how the microbiota and metabolites influence the intestinal epithelium through chromatin, demonstrating a physiological setting in which histone acylations are dynamically regulated and associated with gene regulation

Together, these findings uncover a regulatory axis connecting RNA damage signaling to DNA repair and highlight a context-dependent role of INTS12 in maintaining genome integrity

Immediate return to normal activities following treatment

Route note: 5-Amino-1MQ is well documented as orally bioavailable and is typically sold and dosed as an oral capsule