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After the impact, the influx of Ca 2+ ions into the cell cytoplasm leads to the phosphorylation/activation of phospholipases that cleave phospholipids into fatty acids, diaglycerols and lysophospholipids like LPC, which initiates signaling cascades that drive inflammation, BBB destruction, demyelination, and protein aggregation in several neurodegenerative contexts [81]

In our study, while there is a significant correlation between autophagy intensity and lumbar intervertebral disc degeneration, we also recognize that confounding factors such as variability in surgical techniques, rehabilitation protocols, and patient lifestyle factors could have a significant impact on postoperative recovery and long-term prognosis

"The advice was it had been considered under S2 (as not prohibited) and therefore effectively S0 did not come into play," he said