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Targeted ferroptosis therapy for alzheimers disease The endothelial cells of the BBB are essential in regulating brain iron uptake, and the Tf/TfR1 pathway is the major route for iron absorption in the brain (Yan and Zhang, 2019)

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Graf and Kastin, who authored the two most comprehensive reviews of DSIP biology (1984 [4] and 1986 [5]), documented extensive preclinical effects without being able to trace them to a single receptor