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Conversely, PDGFBB binds both PDGFR and PDGFR, making it very potent in recruiting pericytes and vascular smooth muscle cells to newly formed vessels, thus enhancing vessel maturation and stability [14]

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However, if the fractures are healed without a deformity or only residual minor endplate changes such as Schmorls nodes, it remains difficult to separate these from a developmental or idiopathic degenerative genesis