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A reduction of TNF- and IL-17 expression by mesenchymal stem cells has been associated with increased IL-10 and kynurenine levels (170), although LPS produces parallel increases in TNF-, IL-10, and IDO activity (173)

Recent research has found a bidirectional interaction between the nervous system and immune system, signifying that systemic inflammation could cause selective neuronal activation (Brea and Veiga-Fernandes, 2022)