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Chiral stationary phases (CSPs) were first employed for chromatographic separations in the late 1970s and are now important tools for drug discovery and development [143,179,341]

Hence, a step-by-step, multimodal approach, which includes a mix of treatments and procedures targeting the melanin synthesis pathways, the anti-inflammatory environment, senescence and vascularity, should be used, along with avoidance of exacerbating factors such as UV light and hormonal contraception (Figure 3)

doi: 10.1111/j.1469-1809.2012.00705.x 114 ShiM.CaoL.LiuH.ZhouY.ZhaoY.XiaY