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Key Points Penile fracture is a rare surgical emergency It involves the traumatic rupture of corpus cavernosa and the tunica albuginea in an erect penis Presents typically during intercourse with a popping sound, pain, and immediate detumescence Diagnosis is mainly clinical and cases require urgent surgical exploration and primary repair

In Vivo estimation of GHK-Cu was done by estimating Cu content of plasma samples using Atomic absorption spectroscopy and further correlating the GHK-Cu levels

Quality GHK-Cu formulations buffer to pH 5.5 using citric acid or sodium phosphate and include chelating agents like EDTA to stabilise the copper complex

Exceeding this daily limit increases the risk of liver toxicity, which can lead to acute liver failure and, in severe cases, the need for a liver transplant