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Occludin KO mice develop chronic inflammation and hyperplasia despite normal mucosal barrier properties The occludin KO mice represented the first in vivo experimental strategy to directly manipulate a TJ protein

Duracin de la actividad biolgica: Pese a la corta vida media plasmtica, los efectos posteriores sobre la expresin de telomerasa y la regulacin pineal persisten sustancialmente ms tiempo (das a semanas) coherente con el papel del Epithalon como molcula de sealizacin que desencadena cambios transcripcionales de mayor duracin en lugar de una actividad dosis-respuesta directa