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As mentioned in the previous paragraphs, in vitro concentration probably was too high to explain a possible clinical effect (Wen et al., 2014), was reported with incubation with the PDE4 inhibitor rolipram, a pharmacologic agent known to affect cAMP/cGMP signaling

Para que la carnitina sea eficiente es necesario combinarla con la prctica de ejercicio fsico a una determinada intensidad ,ya que la utilizacin de un sustrato energtico u otro depende de la intensidad con la que se realice el ejercicio