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In U 13 C-glucose tracing, m + 6 labeling of fructose-1,6-bisphosphate (FBP) and fructose-6-phosphate (F6P) is derived from forward flow in glycolysis, and m + 3 labeling from backward flow of 1 labeled and 1 unlabeled triose phosphate through aldolase (Fig

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However, retrospective studies have shown that CU is uncommon in elderly patients, and elderly CU patients have a shorter course of disease than younger CU patients