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Notably, a phase I clinical trial of the MCT1 inhibitor AZD3965 for advanced solid tumors (NCT01791595) has been completed, laying the groundwork for future clinical development

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Combination of RUNX1 inhibitor and gemcitabine mitigates chemo-resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2-axis-mediated endoplasmic reticulum stress

However, IGF-1 levels did not differ between patients with MDD and schizophrenia, which suggests that IGF-1 level is not a specific marker of MDD or schizophrenia