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In addition, TMT exposure can trigger neuroinflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as TNF-, IL-1, and nitric oxide, and increased gene expression of the glial fibrillary acidic protein and activated microglia in the brain

In the electron transport chain (ETC), oxygen is partially reduced by the incorporation of an electron, generating a free radical as a secondary product (Venditti et al., 2013)

Adequate micronutrient supplementations are indicated, in addition to supplemental antioxidants, in conditions of suspected mitochondrial dysfunction and periods of oxidative stress