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however, they share the same goal of facilitating ideal characteristics and ensuring safety, including (i) being readily metabolized and eliminated from the body after accomplishing their desired biological functions, without cytotoxicity-derived byproducts, and (ii) possessing a suitable half-life that is compatible with the therapeutic period of targeted disease (Li and Li, 2014)

To the best of our knowledge, this was the first study of a potential therapy targeting the glycocalyx in sepsis to demonstrate that it can be restored by an exogenous substance (138)