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GHRH activates the GHRH receptor (GHRH-R) by stimulating intracellular cAMP levels, resulting in GH secretion (Mayo, 1992)

Overall, the combination of artemisinin with different chemotherapy agents and other natural compounds demonstrates significant anti-tumor effects, including enhancing the anti-proliferation, pro-apoptotic, and cell cycle regulation effects of oxaliplatin, metformin, and carboplatin on various cancer cell lines