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The cycling recommendation stems from lack of long-term human safety data chronic copper ion delivery beyond 6 months has not been studied in controlled trials

In the blood stream as nicotinic acid, it can cause skin flush and this reaction is actually responsible for the tolerable upper limit (UL) for niacin at 35 mg/d for adults in US (20)

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This mineral is an important part of the structure and properties of cobalamin, plus its the primary mineral that aids rumen microorganismslargely bacteriain synthesizing cobalamin, as well as their growth