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Related to epigenetic considerations, the level of mtDNA mutations positively correlates with BACE1 activity in aging, DS, and DSAD specimens, whereas mtDNA copy number is inversely correlated with insoluble A40 and A42 levels (437)

J Obsessive Compuls Relat Disord 2013;2:4852

Considering that monosaccharide uptake is transporter-mediated, it can be deduced that their entry to the cytoplasm is governed by two principles: (i) the concentration of the monosaccharide in the extracellular space, and (ii) the affinity of the transporters