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Pathophysiology of MSL Hypothesis 1: Brown Adipose Tissue The dorsocervical fat pad (buffalo hump) is thought to be a location of brown adipose tissue found both in MSL (264,269,270) and HIV-associated lipodystrophy (271-274) suggesting that the abnormal fat tissue in both of these conditions arises from brown adipocytes (275)

( However, we previously observed in whole-animal experiments that not only the 2 AR-selective antagonist ICI-118551 but also the 1 AR-selective antagonist CGP20712A reduced tyramine-stimulated norepinephrine release in both spontaneously hypertensive (SHR) and normotensive (WKY) rats ( 1 AR, facilitating release of norepinephrine and epinephrine