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The decline of AMPK activity has been reported to be associated with aging, and the reduction of AMPK activity may contribute to the onset of various age-related diseases

doi: 10.1007/s00253-012-4502-5 29 GeadaP.MoreiraC.SilvaM.NunesR.MadureiraL.RochaC

Furthermore, to mitigate the influence arising from energy disparities, their overall energy content was essentially equated in the final analysis (~600 kJ)